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KMID : 0615720030200030015
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Jouranl of Korean Acupuncture and Moxibustion society
2003 Volume.20 No. 3 p.15 ~ p.23
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The Effects of 120Hz Electroacupuncture on the Prostaglandin E2 and Spinal N-Methyl-D-Aspartate Receptor Expression in the Carrageenan-Injected Rat
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Abstract
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Objective : The role of high frequency 120 Hz electroacupuncture(EA) in carrageenan-induced pain was studied by examining the alnalgesic effects, and prostaglandin E_2(PGE_2) levels measurement and spinal N-methyl-D-aspartate(NMDA) receptor expression. Inflammation was induced by an intraplantar injection of 1% carrageenan into the right hind paw.
Method : Bilateral EA stimulation with 120 Hz were delivered at those acupoints corresponding to Zusanli and Sanyinjiao in man via the needles for a total of 30 min duration in carrageenan-injected rats.
Results : EA stimulation showed significant analgesic effects as measured by analgesy-meter at all time points tested compared with controls. Three hours after carrageenan injection, PGE2 levels were measured by commercial kit. EA significantly inhibited PGE2 production in the right paw. The number of NRI and NR2A, NMDA receptor, immunoreactive neurons was significantly increased in the superficial dorsal horn(laminaeⅠ-Ⅱ) and nucleus proprius(laminaeⅢ-Ⅳ) of ipsilateral spinal cord at L4-5. But the number of carrageenan-induced NRI and NR2A immunoreactive neuron, especially NRI immunoreaction in the superficial dorsal horn, was reduced by 120 Hz EA stimulation.
Conclusions : These results indicate that NMDA receptors may mediate transmission of nociceptive information originating in tissue inflammation of hind paw and high frequency 120 Hz EA stimulation have an alleviating action against local inflammatory pain.
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